PA-477 Building a national network for inpatient pediatric clinical research in Mozambique

BackgroundUniversidade Eduardo Mondlane (UEM) and Hospital Central de Maputo (HCM) were invited to join a consortium of established pediatric research groups from 5 other sub-Saharan Africa countries in a proposal for the EMPIRICAL trial, which received EDCTP funding in 2019 (RIA2017MC-2013). At tha...

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Published in:BMJ global health 2023-12, Vol.8 (Suppl 10), p.A88-A88
Main Authors: Sacarlal, Jahit, Chris Buck, W, Passanduca, Alfeu, Macassa, Eugénia, Saíde, Alarquia, Chhaganlal, Kajal, Gafur, Merunissa, Seni, Amir, Machava, Sara, Martins, Luzidina, Issa, Faiaz, Macanze, Eleutéria, Manjate, Nádia, Chaúque, Sílvia, Langa, Stella, Sidat, Muhammad, Cassia, Uneisse, Salimo, Atija, Mavume, Celda, Massitela, Cláudia, Maieca, Alice, Joaquim, Winete, Martins, Sónia, Adriano, Quim, Zandamela, Mastalina, Bramugy, Justina, Bassat, Quique, Moraleda, Cinta, Tagarro, Alfredo, Sharland, Mike, Rojo, Pablo
Format: Article
Language:English
Subjects:
Abstracts of Poster and e-Poster Presentations
Collaboration
Consortia
Pediatrics
Recruitment
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Summary:BackgroundUniversidade Eduardo Mondlane (UEM) and Hospital Central de Maputo (HCM) were invited to join a consortium of established pediatric research groups from 5 other sub-Saharan Africa countries in a proposal for the EMPIRICAL trial, which received EDCTP funding in 2019 (RIA2017MC-2013). At that time, HCM and UEM did not have an active pediatric research team, nor a history of collaboration on a pediatric clinical trial. MethodsA research office was established on the HCM pediatric wards. Procurement and laboratory cooperation was established with another Mozambique recruiting site, Centro de Investigação em Saúde de Manhiça. Dedicated and part-time staff were hired, including an HCM pediatrician and nurse. Comprehensive research training was conducted, and the first EMPIRICAL patient was recruited in May 2020. Due to slow recruitment across the consortium, UEM agreed to extend to an additional 3 hospitals in Maputo, again including Ministry of Health staff at each new site. Recruitment was similarly extended to the principal referral/academic hospitals in the other regions of Mozambique with inclusion of Hospital Central de Beira in 2020 and Hospital Central de Nampula in 2021, in partnership with Universidade Católica de Moçambique and Universidade Lúrio. This network has led recruitment in EMPIRICAL, is participating in four pharmacokinetic substudies and an autopsy substudy, and has 2 local ancillary studies, one with EDCTP Career Development Fellowship support (TMA2020CDF-3217).ResultsThe infrastructure and capacity established through EMPIRICAL has been leveraged for additional pediatric inpatient research opportunties, with UEM leading 4 hospitals participating in the EDCTP-funded PediCAP trial (RIA2017MC-2023), and 2 hospitals in the UNITED-meningitis diagnostic study.ConclusionA successful pediatric inpatient research network was quickly established in Mozambique with donor support that facilitated capacity building, and a model that prioritized inclusion of Ministry of Health hospital staff in research teams with inter-institutional collaboration to achieve national coverage.
ISSN:2059-7908
DOI:10.1136/bmjgh-2023-EDC.214