Laser-Ablated Zinc Oxide Nanoparticles and Evaluation of Their Antibacterial and Anticancer Activity Against an Ovarian Cancer Cell Line: In Vitro Study

Zinc oxide nanoparticles (ZnO NPs) were formed in the present paper, employing a pulsed laser irradiation approach on a pure zinc target surrounding double deionized water. The structure, morphology, chemical bonding, and optical characteristics of prepared ZnO nanoparticles were investigated using...

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Published in:Plasmonics (Norwell, Mass.) Mass.), 2023-12, Vol.18 (6), p.2091-2101
Main Authors: Hadi, Ali J., Nayef, Uday M., Mutlak, Falah A.-H., Jabir, Majid S.
Format: Article
Language:English
Subjects:
Ablation
Anticancer properties
Biochemistry
Biological and Medical Physics
Biomedical materials
Biophysics
Biotechnology
Chemical bonds
Chemistry
Chemistry and Materials Science
Deionization
E coli
Fourier transforms
Infrared spectrophotometers
Infrared spectroscopy
Irradiation
Lasers
Nanoparticles
Nanotechnology
Optical properties
Ovarian cancer
Pulsed lasers
Spectrum analysis
Wurtzite
Zinc oxide
Zinc oxides
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Summary:Zinc oxide nanoparticles (ZnO NPs) were formed in the present paper, employing a pulsed laser irradiation approach on a pure zinc target surrounding double deionized water. The structure, morphology, chemical bonding, and optical characteristics of prepared ZnO nanoparticles were investigated using X-ray diffraction, transmission electron microscopy, spectrophotometer, and Fourier-transform infrared spectroscopy. The nanoparticles have a nanocrystalline structure with a hexagonal wurtzite arrangement and are spherical with diameters ranging from 5 to 60 nm depending on the laser energy. The analysis of ultraviolet–visible spectroscopy shows a blue shift with decreasing laser energy, and the optical energy bandgap increases as particle size decreases. The FTIR spectrum of ZnO nanoparticles identified at 512.37 cm −1 and 448.63 cm −1 was ascribed to Zn–O-Zn stretching vibrations. However, using the agar well diffusion technique, ZnO nanoparticles were tested for their antibacterial properties towards two distinct strains of bacteria. Antibacterial inspection demonstrated that ZnO nanoparticles were most effective against Staphylococcus aureus , followed by Escherichia coli . Furthermore, the anticancer potential treated with the ZnO nanoparticles was evaluated against the ovarian tumor cell line (SKOV-3), as well as the results suggest that the nanoparticles can function against an antiproliferative agent towards SKOV-3 cells. The present work illustrates the promise of biomedical applications of ZnO nanoparticles obtained by laser irradiation in water.
ISSN:1557-1955
1557-1963
DOI:10.1007/s11468-023-01933-7