Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate

Biopolymers, in particular polysaccharides, have attracted considerable interest in the field of drug delivery due to their biodegradable and biocompatible nature. This study is focused on the preparation and characterization of drug delivery devices based on sodium alginate (SA) composite films wit...

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Bibliographic Details
Published in:Polymers & polymer composites 2021-11, Vol.29 (9_suppl), p.S143-S153
Main Authors: Sarwar, M Sohail, Ghaffar, Abdul, Huang, Qingrong
Format: Article
Language:English
Subjects:
Acids
Biocompatibility
Biopolymers
Calcium chloride
Contact angle
Deionization
Drug delivery systems
Flat surfaces
Fourier transforms
Gram-positive bacteria
Hydrochloric acid
Hydrogels
Hydrogen bonding
Hydrogen chloride
Hydrophobicity
Infections
Molecular interactions
Morphology
Phase separation
Physiochemistry
Polymer films
Polymers
Polysaccharides
Potassium
Sodium
Sodium alginate
Spectrum analysis
Surface properties
Viscosity
Wound healing
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Summary:Biopolymers, in particular polysaccharides, have attracted considerable interest in the field of drug delivery due to their biodegradable and biocompatible nature. This study is focused on the preparation and characterization of drug delivery devices based on sodium alginate (SA) composite films with poly(sodium 4-styrenesulfonate) (PSS). The prepared composite films were characterized for the determination of physiochemical properties, molecular interactions, and drug release behavior. The possible intermolecular hydrogen bonding between SA and PSS was determined by ATR-FTIR spectroscopy. Surface characterization was done using AFM. Polymeric films consisted of pristine SA and PSS exhibited relatively uniform and flat surfaces. However, the composite films showed phase separation that became more prominent as the concentration of PSS in the composite films was increased up to 40% (w/w). The contact angle (CA) values, using deionized water as a function of time (s), were ranging from 74° to 90°, and a decrease in CA (64° to 76°) was recorded for each composite film till 40 s. These CA values revealed that all the composite films were hydrophobic. It was observed that as the concentration of PSS in the films increased, hydrophobicity slightly varied as compared to the blank films of SA and PSS. Maximum CA (89°) was shown by a composite film having SA/PSS (90/10). Ciprofloxacin hydrochloride monohydrate (CPX), a model drug, loaded in a suitable composite film (cross-linked with 0.3 M CaCl2 solution) and drug release was evaluated in pH 1.2 simulated gastric fluid (SGF) and pH 7.4 phosphate buffer saline (PBS) solution. In SGF, around 90% of the model drug was released in 110 min that was approximately 77% in the case of PBS. Therefore, it was concluded that a sustained drug release behavior was exhibited in SGF as compared to PBS solution. These results suggest that these films are a promising and may potentially be subjected to study further their drug delivery behavior in applications like wound dressing.
ISSN:0967-3911
1478-2391
DOI:10.1177/0967391121990278