Prevalence and risk factors associated with drug-resistant epilepsy in adult epileptic patients

BackgroundDespite the plethora of pharmacotherapy and acquisition of new AEDs, there is a hard core of patients who persistently fail to respond to optimal treatment and continue to suffer from refractory seizures. We aimed to study the prevalence and risk factors for development of drug-resistant e...

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Bibliographic Details
Published in:The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Psychiatry and Neurosurgery, 2023-11, Vol.59 (1), p.153-8
Main Authors: Marouf, Hazem, Mohamed, Lobna A, El Ftatary, Amr, Gaber, Dina Elsayed
Format: Article
Language:English
Subjects:
Convulsions & seizures
Drug resistance
Epilepsy
Risk factors
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Summary:BackgroundDespite the plethora of pharmacotherapy and acquisition of new AEDs, there is a hard core of patients who persistently fail to respond to optimal treatment and continue to suffer from refractory seizures. We aimed to study the prevalence and risk factors for development of drug-resistant epilepsy (DRE). All adult patients with epilepsy (PWE) who attended the epilepsy outpatient clinic and were maintained on at least two anti-epileptic drugs (AEDs) were profiled for drug response in accordance with the International League against Epilepsy (ILAE) 2010 consensus definition for DRE. Data collected included demographics, detailed history of seizures, medications history, past medical and psychiatric history, electroencephalogram, and brain imaging findings.ResultsThe prevalence rate of DRE was 21.3% in the study population. Significant variables on univariate analysis were the following: male gender (OR: 5.409, CI 1.661–17.617, p 
ISSN:1110-1083
1687-8329
DOI:10.1186/s41983-023-00750-3