Cutaneous rhabdomyosarcoma with FUS::TFCP2 fusion: A case report emphasizing early detection

Abstract Rhabdomyosarcoma with TFCP2 rearrangement is a recently identified malignant neoplasm characterized by immunohistochemical evidence of rhabdomyoblastic differentiation, keratin expression, upregulation of ALK, and an aggressive clinical course. This neoplasm has a tendency to affect craniof...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2023-12, Vol.50 (12), p.1059-1064
Main Authors: Demirkesen, Cuyan, Danyeli, Ayça Erşen, Yıldız, Pelin, Ertekin, Sümeyre Seda, Yılmaz, Berkhan, Karahan, Süleyman İzzet, Bahrami, Armita
Format: Article
Language:English
Subjects:
Case reports
Dermatitis
Keratin
Neoplasia
Rhabdomyosarcoma
Tumors
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Summary:Abstract Rhabdomyosarcoma with TFCP2 rearrangement is a recently identified malignant neoplasm characterized by immunohistochemical evidence of rhabdomyoblastic differentiation, keratin expression, upregulation of ALK, and an aggressive clinical course. This neoplasm has a tendency to affect craniofacial bones, with only a few reported cases of extra‐osseous tumors. Here, we present a case of cutaneous rhabdomyosarcoma with FUS::TFCP2 fusion in a 35‐year‐old female. Notably, the tumor exhibited a pathologic spectrum, initially resembling sclerosing dermatitis at presentation but progressing into a high‐grade malignant tumor within 8 months. The distinctive immunoprofile of this neoplasm highlights the importance of early molecular studies for diagnosis, even in the presence of low‐grade cytomorphology. Early detection may offer an opportunity for timely resection before the tumor becomes unresectable.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14526