Inhalation of smoke from burning tire triggers oxidative stress and impairs liver and kidney functions in rats

In Nigeria, abattoir workers use scrap tires as a source of fuel to remove furs from slaughtered animals. The smoke from the tires contains particulate matter (PM), and inhalation of the PM is associated with undesirable toxic effects such as cardiopulmonary toxicity. This study investigated the tox...

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Bibliographic Details
Published in:Comparative clinical pathology 2023-10, Vol.32 (5), p.837-846
Main Authors: Obasi, Ifeanyi Chima, Ohaeri, Obioma Christopher, Ijioma, Solomon Nnah, Okoro, Benedict Chukwuebuka, Ugbogu, Eziuche Amadike
Format: Article
Language:English
Subjects:
Abattoirs
Alanine transaminase
Alkaline phosphatase
Alveoli
Aspartate transaminase
Burning
Cell size
Erythrocytes
Glutathione peroxidase
Hematology
Hemoglobin
Hemorrhage
Hepatotoxicity
Inhalation
Kidneys
Leukocytes
Liver
Medicine
Medicine & Public Health
Oncology
Original Article
Oxidative stress
Particulate matter
Pathology
Smoke
Steatosis
Tires
Toxicity
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Summary:In Nigeria, abattoir workers use scrap tires as a source of fuel to remove furs from slaughtered animals. The smoke from the tires contains particulate matter (PM), and inhalation of the PM is associated with undesirable toxic effects such as cardiopulmonary toxicity. This study investigated the toxicological effects of smoke from the burning tire in male Wistar rats. The experimental rats were assigned into five (5) groups of 5 rats in each group. Group 1 served as the normal control (not exposed to smokes from the burning tire), while groups 2–5 were exposed to 10 mg/m 3 PM 10 smoke from burning tire once daily for 15, 30, 60, and 120 min, respectively, for 21 days. The rats were sacrificed, and the toxicity profile was measured by evaluating the hematological and biochemical parameters along with the liver, heart, kidney, and lung histology. Our results showed that smokes from tire significantly ( P  
ISSN:1618-565X
1618-5641
1618-565X
DOI:10.1007/s00580-023-03493-y