Two truxinate derivatives and a phenyldilactone from the leaves of Castanopsis eyrei

Phytochemical investigation of the Leaves of Castanopsis eyrei led to the isolation of two new natural truxinate derivatives and a new phenyldilactone. The structures of the new natural compounds were determined by spectroscopic methods and chemical evidence as 3,3',4,4'-tetrahydroxy-β-tru...

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Bibliographic Details
Published in:Natural product research 2023-11, Vol.37 (21), p.3605-3609
Main Authors: Wang, Ya-feng, Pang, Nao, Liang, Zhen-hua, Huang, Yong-lin, He, Rui-jie, Yang, Bing-yuan, Liu, Zhang-bin
Format: Article
Language:English
Subjects:
activity in reducing lipid accumulation
Castanopsis eyrei
Lipid metabolism
Lipids
structure
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Summary:Phytochemical investigation of the Leaves of Castanopsis eyrei led to the isolation of two new natural truxinate derivatives and a new phenyldilactone. The structures of the new natural compounds were determined by spectroscopic methods and chemical evidence as 3,3',4,4'-tetrahydroxy-β-truxillic acid (1), 3,3',4,4'-tetrahydroxy-δ-truxillic acid (2), 3'-hydroxymaysedilactone A (3). Establishment of a Caenorhabditis elegans lipid metabolism model using GFP and mCherry fluorescently labeled lipid droplets to screen compound 3 for its activity in reducing lipid accumulation.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2095636