Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells

This paper studies the preparation of a carbohydrate derivative of lipotripeptide ( N -lactitol-Gly) 2 -LysC 16 of an irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent labe...

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Bibliographic Details
Published in:Moscow University chemistry bulletin 2023-10, Vol.78 (5), p.283-291
Main Authors: Afanasyeva, K. A., Gileva, A. M., Markvicheva, E. A., Budanova, U. A., Sebyakin, Y. L.
Format: Article
Language:English
Subjects:
Carbohydrates
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Fluorescence
Galactose
Lactose
Lysine
Original Article
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Summary:This paper studies the preparation of a carbohydrate derivative of lipotripeptide ( N -lactitol-Gly) 2 -LysC 16 of an irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent label in a hydrophobic fragment. The developed synthesis scheme includes universal approaches of peptide chemistry and the stages of the formation of an acyclic carbohydrate based on lactose in the hydrophilic domain of amphiphile. The compounds are designed to create compositions of the vector BAS delivery systems with the ability to visualize the process of interaction with the target cells.
ISSN:0027-1314
1935-0260
DOI:10.3103/S0027131423050036