Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids

Synthesis and intramolecular cyclization of the substituted 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids were studied. It was found that the synthesized compounds underwent the intramolecular cyclization to give the substituted ethyl 4-(4-chlorophe...

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Bibliographic Details
Published in:Russian chemical bulletin 2023-09, Vol.72 (9), p.2255-2262
Main Authors: Gorbunova, I. A., Nikonov, I. P., Makhmudov, R. R., Shipilovskikh, D. A., Silaichev, P. S., Shipilovskikh, S. A.
Format: Article
Language:English
Subjects:
Aromatic compounds
Biological activity
Carboxylates
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
Substitutes
Synthesis
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Summary:Synthesis and intramolecular cyclization of the substituted 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids were studied. It was found that the synthesized compounds underwent the intramolecular cyclization to give the substituted ethyl 4-(4-chlorophenyl)-2-{[2-oxofuran-3(2 H )-ylidene]-amino}thiophene-3-carboxylates. Evaluation of the biological activity of the synthesized compounds showed that they have pronounced antinociceptive activity along with low toxicity.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-023-4023-7