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Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue
A generic strategy to construct virus protein-based hybrid nanomaterials is reported by using a macromolecular glue inspired by mussel adhesion. Commercially available poly(isobutylene- alt -maleic anhydride) (PiBMA) modified with dopamine (PiBMAD) is designed as this macromolecular glue, which serv...
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Published in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-08, Vol.11 (33), p.7933-7941 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | A generic strategy to construct virus protein-based hybrid nanomaterials is reported by using a macromolecular glue inspired by mussel adhesion. Commercially available poly(isobutylene-
alt
-maleic anhydride) (PiBMA) modified with dopamine (PiBMAD) is designed as this macromolecular glue, which serves as a universal adhesive material for the construction of multicomponent hybrid nanomaterials. As a proof of concept, gold nanorods (AuNRs) and single-walled carbon nanotubes (SWCNTs) are initially coated with PiBMAD. Subsequently, viral capsid proteins from the Cowpea Chlorotic Mottle Virus (CCMV) assemble around the nano-objects templated by the negative charges of the glue. With virtually unchanged properties of the rods and tubes, the hybrid materials might show improved biocompatibility and can be used in future studies toward cell uptake and delivery.
A dopamine based macromolecular glue is used to facilitate the construction of hybrid nanomaterials that are coated with virus capsid proteins, with the aim to improve stability, biocompatibility, and function. |
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ISSN: | 2050-750X 2050-7518 |
DOI: | 10.1039/d2tb02688k |