Etiologic and prognostic roles of frailty, multimorbidity and socioeconomic characteristics in the development of SARS-CoV-2 infection and related severe health outcomes: systematic reviews of population-based studies

The study had 2 objectives, to: 1) evaluate the etiologic roles of frailty, multimorbidity and socioeconomic status on SARS-CoV-2 infection probability, hospitalization, intensive care unit (ICU) admission, mechanical ventilation and COVID-19 related mortality; 2) investigate the prognostic roles of...

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Bibliographic Details
Published in:European journal of public health 2022-10, Vol.32 (Supplement_3)
Main Authors: Makovski, T, Ghattas, J, Devleesschauwer, B, Carcaillon-Bentata, L
Format: Article
Language:English
Subjects:
Archives & records
Comorbidity
COVID-19
Deprivation
Etiology
Frailty
Hospitalization
Literature reviews
Mechanical ventilation
Medical prognosis
Mental health
Mortality
Multimorbidity
Objectives
Population
Population studies
Population-based studies
Public health
Quality of life
Registration
Reviews
Risk factors
Severe acute respiratory syndrome coronavirus 2
Socioeconomic factors
Socioeconomic status
Socioeconomics
Systematic review
Ventilation
Ventilators
Viral diseases
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Description
Summary:The study had 2 objectives, to: 1) evaluate the etiologic roles of frailty, multimorbidity and socioeconomic status on SARS-CoV-2 infection probability, hospitalization, intensive care unit (ICU) admission, mechanical ventilation and COVID-19 related mortality; 2) investigate the prognostic roles of mentioned risk factors on the likelihood of hospitalization, ICU admission, mechanical ventilation, COVID-19 mortality, functioning, quality of life, disability, mental health and work absence. Three systematic reviews were performed, for each risk factor. The reviews shared first screening steps relying on a common population-based approach. Initial search took place on 7 April 2021 in PubMed, Embase, PsycINFO and WHO Covid-19 database. An update was performed for frailty only, on 1 February 2022, due to the scarce literature retained initially. Prospero registration number: CRD42021249444. Initial search retrieved 10 139 records; 411 studies were read in full text. An update for frailty retrieved 565 records. Finally, the total number of included studies was: for multimorbidity, objective 1 N = 2, objective 2 N = 13; frailty, objective 1 N = 2, objective 2 N = 3; socioeconomic characteristics, objective 1 N = 57, objective 2 N = 30. The risk of severe short-term outcomes such as mortality, ICU admission or hospitalization increased with increasing disease burden and socioeconomic deprivation. Literature on long-term impacts was not identified. The evidence indicates a dose-effect association across all risk factors and outcomes. There is a lack of work conducted on population-based representative samples accounting for frailty and multimorbidity. Measures of multimorbidity and frailty were heterogeneous between studies. Most of the studies observing socioeconomic determinants were performed in the USA and the UK; hence the need for more research in different contexts. Further evidence is required in order to estimate the impact of crisis among general population.
ISSN:1101-1262
1464-360X
DOI:10.1093/eurpub/ckac129.062