Synthesis of New 9-Substituted Derivatives of 2-Oxomethylcytisine

New derivatives of 3-methylcytisine with 9-aromatic substituents bonded to the pyridone core of the starting alkaloid through spacers of various natures, e.g., aminomethyl, amide, thio- and carboxamide, ethenyl, and ethyl, were synthesized from 9-amino- and 9-bromo-2-oxomethylcytisine.

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Bibliographic Details
Published in:Chemistry of natural compounds 2023-07, Vol.59 (4), p.738-742
Main Authors: Koval′skaya, A. V., Lobov, A. N., Sorokina, V. A., Tsypysheva, I. P., Dokichev, V. A.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Organic Chemistry
Plant metabolites
Plant Sciences
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Description
Summary:New derivatives of 3-methylcytisine with 9-aromatic substituents bonded to the pyridone core of the starting alkaloid through spacers of various natures, e.g., aminomethyl, amide, thio- and carboxamide, ethenyl, and ethyl, were synthesized from 9-amino- and 9-bromo-2-oxomethylcytisine.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-023-04099-0