Contribution of 68Ga-PSMA PET/CT to targeting volume delineation of prostate cancer treated with conformal radiation therapy: Which SUV threshold is appropriate?

Introduction: Prostate-specific membrane antigen (PSMA) has been demonstrated as a promising tool for specific imaging of prostate cancer (PCa) via positron emission tomography-computed tomography (PET/CT) scanning. Radiation treatment planning (RTP) based on 68Ga-PSMA PET/CT scanning can also lead...

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Published in:Majallahī-i pizishk-i hastahī Īrān 2020-07, Vol.28 (2), p.20
Main Authors: Vajiheh Vejdani Noghreiyan, Emami, Farshad, Salek, Roham, Nasseri, Shahrokh, Vosoughi, Habibeh, Momennezhad, Mehdi
Format: Article
Language:English
Subjects:
Antigens
Comparative studies
Computed tomography
Delineation
Image segmentation
Medical imaging
Organs
Planning
Positron emission
Prostate cancer
Radiation
Radiation dosage
Radiation effects
Radiation therapy
Scanning
Tomography
Tumors
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Summary:Introduction: Prostate-specific membrane antigen (PSMA) has been demonstrated as a promising tool for specific imaging of prostate cancer (PCa) via positron emission tomography-computed tomography (PET/CT) scanning. Radiation treatment planning (RTP) based on 68Ga-PSMA PET/CT scanning can also lead to some decision modifications. The specific goal of this comparative study is to show how 68Ga-PSMA PET/CT images can influence the target volume delineation (TVD) and normal tissue radiation dose for PCa RTP, and to compare gross tumor volumes (GTVs) delineated using various strategies for 68Ga-PSMA PET-based image segmentation techniques. Methods: This study consisted of eleven 68Ga-PSMA PET/CT images related to patients affected with locally advanced PCa. Four strategies also included manual segmentation techniques, a 2.5 standardized uptake value (SUV) cutoff (SUV=2.5), as well as a fixed threshold of 40% and 50% of the maximum signal intensity (SUV=%40 SUVmax and SUV=%50 SUVmax) for 68Ga-PSMA PET-based segmentation techniques to delineate GTVPET. Two treatment planning were accordingly generated for each patient based on manual GTVPET and CT-only. Results: The GTV was statistically and significantly smaller for PET/CT-derived volumes (9.39 vs. 77.98 cm3 for CT alone) (p
ISSN:1681-2824