Does bone marrow affect the radiological outcome when added to biphasic ceramic graft in treatment of benign bone lesions?

Purpose The aim of this study is to describe the role of bone marrow aspirate in treatment of the benign bone lesions by comparing two groups of patients (16 patients in each group) with benign bone lesions treated with surgical curettage and filling the defect with either composite ceramic graft hy...

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Bibliographic Details
Published in:European journal of orthopaedic surgery & traumatology 2013, Vol.23 (1), p.13-20
Main Authors: El-Adl, Gamal, Ali, Ayman M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
Bone Diseases - diagnostic imaging
Bone Diseases - surgery
Bone marrow
Bone Marrow - physiology
Bone Marrow - surgery
Bone Marrow Transplantation - methods
Bone Substitutes - therapeutic use
Ceramics - pharmacokinetics
Ceramics - therapeutic use
Curettage
Female
Humans
Hydroxyapatites - pharmacokinetics
Hydroxyapatites - therapeutic use
Male
Medicine
Medicine & Public Health
Original Article
Prospective Studies
Radiography
Surgical Orthopedics
Traumatic Surgery
Treatment Outcome
Young Adult
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Summary:Purpose The aim of this study is to describe the role of bone marrow aspirate in treatment of the benign bone lesions by comparing two groups of patients (16 patients in each group) with benign bone lesions treated with surgical curettage and filling the defect with either composite ceramic graft hydrated with bone marrow aspirate “group 1” or composite ceramic graft alone without a bone marrow aspirate “group 2”. Materials and methods The mean age was 19.7 years (group 1) and 18.5 years (group 2). The mean size of the cavitary bone lesions was 29.2 cm 2 (group 1) and 25.9 cm 2 (group 2). The mean follow-up period was 47 months. Results The percentage of ceraform resorption had increased from 31.3% at 6 months to 75.4% at 36 months for group 1 patients and from 20.9% at 6 months to 60.3% at 36 months for group 2 patients. The percentage of bone trabeculation through the cavitary defects had increased from 30.3% at 6 months to 85.5% at 36 months for group 1 patients and from 18.9% at 6 months to 72.0% at 36 months for group 2 patients. The mean of the percentage of ceraform persistence at 36 months after its implantation was 24.6% for group 1 patients and 39.7% for group 2 patients. Conclusion Adding bone marrow aspirate to ceraform biphasic ceramic had hastened the rate of its resorption and had decreased the rate of its persistence.
ISSN:1633-8065
1432-1068
DOI:10.1007/s00590-012-0943-x