Synthesis, Spectral Characterization, and Antimicrobial Activity of Novel Biginelli-Type Compounds Containing Sulfaguanidine

Refluxing of 2,4,5-trimethoxyacetophenone with dimethyl formamide dimethyl acetal (DMF-DMA) in absence of solvent for 12 h resulted in the synthesis of enaminone, (2 E )-3-(dimethylamino)-1-(2,4,5-trimethoxyphenyl)prop-2-en-1-one. Novel Biginelli-type compounds containing sulfaguanidine moiety were...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-04, Vol.93 (4), p.931-936
Main Authors: Bhat, M. A., Naglah, A. M., Khan, A. A., Al-Omar, M. A., Aleanizy, F. S., Eltayb, E. K., Alqahtani, F. Y.
Format: Article
Language:English
Subjects:
Acetic acid
Antiinfectives and antibacterials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Dimethyl acetals
Dimethylformamide
Heterocyclic compounds
Organic acids
Refluxing
Synthesis
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Summary:Refluxing of 2,4,5-trimethoxyacetophenone with dimethyl formamide dimethyl acetal (DMF-DMA) in absence of solvent for 12 h resulted in the synthesis of enaminone, (2 E )-3-(dimethylamino)-1-(2,4,5-trimethoxyphenyl)prop-2-en-1-one. Novel Biginelli-type compounds containing sulfaguanidine moiety were obtained by reacting the enaminone with sulfaguanidine, substituted benzaldehydes, and glacial acetic acid. All the prepared compounds were tested for antimicrobial activity by the agar diffusion method. Most of the compounds were active against gram-positive and gram-negative bacteria.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223040217