In Vitro Antimicrobial and in Vivo Molluscicidal Potentialities of Fe(III), Co(II) and Ni(II) Complexes Incorporating Symmetrical Tetradentate Schiff Bases (N2O2)

This paper aimed at synthesizing symmetrical Schiff base ligands derived from the primary amine 1,2-bis(2-aminophenylthio)ethane condensed with 7-formyl-8-hydroxyquinoline and 2-hydroxy-1-naphthaldehyde. The synthesised ligands were used for preparing metal complexes with the iron triad metals. The...

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Bibliographic Details
Published in:Oriental journal of chemistry 2020-01, Vol.36 (3), p.373-384
Main Authors: M. Alosaimi, Amal, Mannoubi, Ines El, A. Zabin, Sami
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Chemical activity
Cooling
Coordination compounds
Ethane
Ethanol
Hydroxyquinoline
Imines
Iron
Laboratories
Ligands
Nickel
Research methodology
Snails
Solvents
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Summary:This paper aimed at synthesizing symmetrical Schiff base ligands derived from the primary amine 1,2-bis(2-aminophenylthio)ethane condensed with 7-formyl-8-hydroxyquinoline and 2-hydroxy-1-naphthaldehyde. The synthesised ligands were used for preparing metal complexes with the iron triad metals. The symmetrical tetradentate (N2O2) Schiff base ligands SL1 and SL2 forms mononuclear complexes with square planar geometry in case of Co(II) and Ni(II) complexes, while an octahedral geometry was obtained for the Fe(III) complexes. The molar conductance quantification showed that the complexes were non-ionic. In vitro antimicrobial potential examination of the free ligands indicated weak activity and the corresponding complexes showed enhanced activity. Moreover, the in vivo molluscicidal potential of the tested chemicals showed good activity against the tested land snails. Ligands showed activity at concentration of 1000 ppm while their metal complexes show activity at concentration of 500 ppm. The highest activity (LC50) of complexes was shown at concentration of 5000 ppm.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/360304