Synthesis and Characterization of Polydopamine Nanoparticles Functionalized with Hyaluronic Acid as a Potentially Targeted Computed Tomography Contrast Agent

In this work, polydopamine nanoparticles (PDA NPs) functionalized with hyaluronic acid (HA) (PDA/HA NPs) are synthesized and chelated with Ba 2+ ions as a potential tumor-targeted computed tomography (CT) CA. The ultraviolet-visible spectroscopy (UV-vis) analyses validate the self-polymerization of...

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Bibliographic Details
Published in:BioNanoScience 2023-06, Vol.13 (2), p.564-575
Main Authors: Shariati, Alireza, Delavari H, Hamid, Poursalehi, Reza
Format: Article
Language:English
Subjects:
Adsorption
Biological and Medical Physics
Biomaterials
Biophysics
Chemisorption
Circuits and Systems
Computed tomography
Contrast agents
Contrast media
Cytotoxicity
Engineering
Hyaluronic acid
Light scattering
Nanoparticles
Nanotechnology
Photon correlation spectroscopy
Scanning electron microscopy
Spectroscopy
Thermal decomposition
Thermogravimetric analysis
Tomography
Toxicity
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Summary:In this work, polydopamine nanoparticles (PDA NPs) functionalized with hyaluronic acid (HA) (PDA/HA NPs) are synthesized and chelated with Ba 2+ ions as a potential tumor-targeted computed tomography (CT) CA. The ultraviolet-visible spectroscopy (UV-vis) analyses validate the self-polymerization of PDA NPs with a distinct absorption peak around 280 nm, and thermogravimetric analysis (TGA) confirms the coating of HA on PDA NPs by the difference in the thermal decomposition process of PDA and PDA/HA NPs. Moreover, the results of dynamic light scattering (DLS) and scanning electron microscopy (SEM) show that the size of spherical PDA/HA NPs generally declines with increasing HA. The results of adsorption isotherms show that the adsorption process of Ba 2+ ions with PDA/HA NPs is favorable chemisorption. The synthesized Ba/PDA/HA NPs show no significant cytotoxicity at Ba 2+ concentration of 1.45 mg/mL and 25 μg/mL for HEK293 and HepG2 cell lines, respectively, and the CT results of Ba/PDA/HA NPs show similar X-ray attenuation to the commercial CT contrast agents. Graphical abstract
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-023-01097-y