Exposure to low-dose arsenic caused teratogenicity and upregulation of proinflammatory cytokines in zebrafish embryos

Arsenic is currently ranked as the most toxicant on the ATSDR 2015 substance priority list and is categorised as a Group 1 human carcinogen. Biota that are subjected to inorganic arsenicals through food, water, occupational or medical exposure pose a risk to the environment and to human health. The...

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Bibliographic Details
Published in:Biological trace element research 2023-07, Vol.201 (7), p.3487-3496
Main Authors: Piyushbhai, Modi Kiran, Binesh, Ambika, Shanmugam, S. A., Venkatachalam, Kaliyamurthi
Format: Article
Language:English
Subjects:
Abnormalities
Animal embryos
Animals
Arsenic
Arsenic - metabolism
Arsenic - toxicity
Arsenic compounds
Arsenicals
Arsenite
Biochemistry
Biomedical and Life Sciences
Biota
Biotechnology
Carcinogens
Catalase
Catalase - metabolism
Cyclooxygenase-2
Cytokines
Cytokines - metabolism
Danio rerio
Embryos
Enzymatic activity
Enzyme activity
Exposure
Fertilization
Freshwater fishes
Glutathione
Glutathione peroxidase
Hatchability
Humans
Inflammation
Interleukin 6
Life Sciences
Malformations
Necrosis
Nutrition
Occupational exposure
Oncology
Oxidative Stress
Peroxidase
Sodium
Sodium arsenite
Startle response
Superoxide dismutase
Superoxide Dismutase - metabolism
Teratogenicity
Toxicants
Toxicity
Toxicity tests
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Turning behavior
Up-Regulation
Zebrafish
Zebrafish - metabolism
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Summary:Arsenic is currently ranked as the most toxicant on the ATSDR 2015 substance priority list and is categorised as a Group 1 human carcinogen. Biota that are subjected to inorganic arsenicals through food, water, occupational or medical exposure pose a risk to the environment and to human health. The present study was carried out to investigate the toxicity caused by inorganic arsenic. After fertilisation, zebrafish embryos were exposed to sodium arsenite at several concentrations (100 nM to 600 nM) for 24 to 96 hpf. The indicators of teratogenicity (hatchability, morphological abnormalities, mortality), behavioural modifications (touch induced escape response (TIER), startle response (SR) and turning behaviour (TB)), biochemical testing (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione S transferase (GST)) and the expressions of tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) were investigated. The aforementioned parameters were found to be altered in embryos exposed to sodium arsenite. According to the findings of the current study, even a low dose of inorganic arsenic compound caused teratogenicity, behavioural abnormalities, altered enzyme activities and the expression of proinflammatory cytokines in zebrafish embryos.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-022-03418-w