Electrooxidative α-hydroxymethylation of ketones with dimethylformamide as the carbon source

An environmentally benign electrochemical approach has been developed for the α-hydroxymethylation of ketones using N , N -dimethylformamide as the carbon source for the construction of β-hydroxy ketones. This method does not require metal catalysts or chemical oxidants and proceeded smoothly at roo...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2023-04, Vol.25 (8), p.316-32
Main Authors: Zheng, Jin-Ming, Li, Yi-Fei, Pan, Yi-Xiang, Hu, Xiao-Dong, Ye, Xiao-Xia, Li, Ren-Hao
Format: Article
Language:English
Subjects:
Carbon
Carbon sources
Catalysts
Dimethylformamide
Electrochemistry
Functional groups
Green chemistry
Ketones
Oxidants
Oxidizing agents
Room temperature
Temperature tolerance
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Summary:An environmentally benign electrochemical approach has been developed for the α-hydroxymethylation of ketones using N , N -dimethylformamide as the carbon source for the construction of β-hydroxy ketones. This method does not require metal catalysts or chemical oxidants and proceeded smoothly at room temperature to demonstrate tolerance of a broad range of functional groups. We report the electrocatalytic α-hydroxymethylation of ketones using DMF as the carbon source at room temperature in air in a conversion that proceeds without need for toxic and expensive chemical oxidants or metal catalysts.
ISSN:1463-9262
1463-9270
DOI:10.1039/d3gc00144j