A randomized, double‐blind placebo‐controlled add‐on trial to assess the efficacy, safety, and anti‐atherogenic effect of spirulina platensis in patients with inadequately controlled type 2 diabetes mellitus

The efficacy of spirulina platensis (S. platensis) as an add‐on therapy to metformin and its effect on atherogenic keys in patients with uncontrolled Type 2 Diabetes Mellitus (T2DM) was evaluated. Sixty patients were randomly assigned to S. platensis (2 g/day) or placebo group for three months while...

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Published in:Phytotherapy research 2023-04, Vol.37 (4), p.1435-1448
Main Authors: Karizi, Sahar rajabzadeh, Armanmehr, Fatemeh, Azadi, Hamideh Ghodrati, Zahroodi, Hojjat Shadman, Ghalibaf, AmirAli Moodi, Bazzaz, Bibi Sedigheh Fazly, Abbaspour, Mohammadreza, Boskabadi, Javad, Eslami, Saeid, Taherzadeh, Zhila
Format: Article
Language:English
Subjects:
atherogenic keys
Cholesterol
Cholesterol, LDL
Cyanobacteria
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - drug therapy
Double-blind studies
Effectiveness
fasting blood glucose
Glucose
Glycated Hemoglobin
hemoglobin A1C
High density lipoprotein
Humans
Hypoglycemic Agents - therapeutic use
Lipids
Low density lipoprotein
Metformin
Metformin - therapeutic use
Placebos
Spirulina platensis
type 2 diabetes
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Summary:The efficacy of spirulina platensis (S. platensis) as an add‐on therapy to metformin and its effect on atherogenic keys in patients with uncontrolled Type 2 Diabetes Mellitus (T2DM) was evaluated. Sixty patients were randomly assigned to S. platensis (2 g/day) or placebo group for three months while continuing metformin as their usual treatment. The efficacy of S. platensis was determined using the pre‐ and post‐intervention HbA1c levels (primary outcome) as well as tracking FBS and lipid profiles levels (TC, LDL‐C, TG, and HDL‐C) as secondary outcomes at the different treatment time points (0,30,60,90 days). During the three–month intervention period, supplementation with S. platensis resulted in a significant lowering of HbA1c (↓1.43, p 
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7674