TAFRO syndrome with fatigue and abdominal distension as the first symptom: A case report

TAFRO syndrome is a peculiar and rare type of multi‐centric Castleman's disease which contained a series of symptoms such as thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Here we provide a case of TAFRO syndrome with the manifestation of fatigue, a...

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Bibliographic Details
Published in:Hematological oncology 2023-04, Vol.41 (2), p.285-290
Main Authors: Zhou, Bai, Tang, Chao, Chen, Guiyang, Jiang, Tiebin, Shi, Xiao, Wang, Fen
Format: Article
Language:English
Subjects:
Biopsy
Case reports
Castleman Disease - complications
Castleman Disease - diagnosis
Castleman Disease - drug therapy
Castleman's disease
Chemotherapy
CHOP
Distension
Edema - diagnosis
Edema - drug therapy
Edema - etiology
Fatigue
Fever
Fibrosis
Hepatitis B
Humans
Lymph nodes
Lymph Nodes - pathology
Lymphadenopathy
Signs and symptoms
TAFRO syndrome
Thrombocytopenia
Viruses
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Summary:TAFRO syndrome is a peculiar and rare type of multi‐centric Castleman's disease which contained a series of symptoms such as thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Here we provide a case of TAFRO syndrome with the manifestation of fatigue, abdominal distension, and low fever at primary diagnosis, characterized by multiple lymphadenopathy of superficial mediastinal and retroperitoneal lymph nodes, and it was finally confirmed by lymph node biopsy. The patient recovered speedy after receiving CHOP chemotherapy. In this case report, the patient has a history of dust‐exposure and hepatitis B virus infection, which may be potentially related to the disease. In addition, this case suggests the importance of pathological biopsy of complete lymph nodes in diagnostic process.
ISSN:0278-0232
1099-1069
DOI:10.1002/hon.2962