Facile, fast and green synthesis of a highly porous calcium-syringate bioMOF with intriguing triple bioactivity

A facile, fast and green strategy based on ethanol is utilized to prepare a new bioMOF, namely, CaSyr-1, with particular characteristics of full biocompatibility given by using just calcium and syringic acid, the latter being a phenolic natural product found in fruits and vegetables, permanent poros...

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Bibliographic Details
Published in:Inorganic chemistry frontiers 2023-03, Vol.10 (7), p.2165-2173
Main Authors: Rosado, Albert, Vallcorba, Oriol, Vázquez-Lasa, Blanca, García-Fernández, Luís, Ramírez-Jiménez, Rosa Ana, María Rosa Aguilar, López-Periago, Ana M, Domingo, Concepción, Ayllón, José A
Format: Article
Language:English
Subjects:
Adsorption
Adsorptivity
Biocompatibility
Biological activity
Calcium ions
Ethanol
Inorganic chemistry
Natural products
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Summary:A facile, fast and green strategy based on ethanol is utilized to prepare a new bioMOF, namely, CaSyr-1, with particular characteristics of full biocompatibility given by using just calcium and syringic acid, the latter being a phenolic natural product found in fruits and vegetables, permanent porosity with an outstanding surface area >1000 m2 g−1, and a micropore diameter of 1.4 nm close to mesopore values. Collectively, these data establish CaSyr-1 as one of the most porous bioMOFs reported to date, with high molecular adsorption capacity. The CaSyr-1 adsorptive behavior is revised here through the reversible adsorption of CO2 and the encapsulation of bioactive ingredients in the structure. Remarkably, CaSyr-1 enables the development of triple therapeutic entities, involving bioactive Ca2+, syringic acid and an impregnated drug.
ISSN:2052-1545
2052-1553
DOI:10.1039/d2qi02639b