An increased disulfide/native thiol ratio and oxidative stress index in metabolic syndrome patients with postprandial lipemia

Background Metabolic syndrome (MetS) is closely related to lipid disorders and increased oxidant stress, and is associated with cardiovascular diseases. Objective The purpose of this research was to examine thiol/disulfide homeostasis and oxidative stress in MetS patients with postprandial lipemia (...

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Published in:International journal of diabetes in developing countries 2023-02, Vol.43 (1), p.125-133
Main Authors: Ozer Yaman, Serap, Balaban Yucesan, Fulya, Orem, Asım, Orem, Cihan, Vanizor Kural, Birgul, Yaman, Huseyin
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Diabetes
Family Medicine
Fasting
General Practice
Health Administration
Homeostasis
Medicine
Medicine & Public Health
Metabolic syndrome
Original Article
Oxidants
Oxidation
Oxidative stress
Postprandial lipemia
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Summary:Background Metabolic syndrome (MetS) is closely related to lipid disorders and increased oxidant stress, and is associated with cardiovascular diseases. Objective The purpose of this research was to examine thiol/disulfide homeostasis and oxidative stress in MetS patients with postprandial lipemia (PPL) during fasting by considering time-dependent changes in the postprandial period. Methods Twenty-five patients with MetS and 25 healthy controls underwent a 6-h oral fat tolerance test. Dynamic thiol/disulfide homeostasis (native thiol, disulfide, and total thiol) values and total oxidant status (TOS), total antioxidant status (TAS), and Oxidative Stress Index (OSI): (TOS/TAS) were evaluated. Results Increased levels of disulfide, and higher disulfide/native thiol ratio, TOS, and OSI values were observed at fasting and in the postprandial period in MetS compared to the control group, peaking at the 4 th hour in both groups ( p < 0.05). ROC analysis showed that both fasting and 4 th hour disulfide/native thiol ratios exhibited the highest values. Higher disulfide/native thiol ratio values were observed at the 4 th hour and higher OSI in the 2 nd hour in the upper tertiles for MetS ( p < 0.05). Conclusions An increased disulfide/native thiol ratio and OSI level elevation in MetS may be closely associated with PPL. The disulfide/native thiol ratio in MetS subjects with PPL may play a role for evaluating oxidative stress, especially in postprandial 4 th hour.
ISSN:0973-3930
1998-3832
DOI:10.1007/s13410-022-01095-y