Identification of protein superfamily from structurebased sequence motif

The structure-based sequence motif of the distant proteins in evolution, protein tyrosine phosphatases (PTP) I and II superfamilies, as an example, has been defined by the structural comparison, structure-based sequence alignment and analyses on substitution patterns of residues in common sequence c...

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Bibliographic Details
Published in:Science bulletin (Beijing) 2002-01, Vol.47 (16), p.1377-1381
Main Authors: Huang Jingfei, Liu Ciquan
Format: Article
Language:English
Subjects:
Conserved sequence
Nucleotide sequence
Proteins
Tyrosine
Online Access:Get full text
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Description
Summary:The structure-based sequence motif of the distant proteins in evolution, protein tyrosine phosphatases (PTP) I and II superfamilies, as an example, has been defined by the structural comparison, structure-based sequence alignment and analyses on substitution patterns of residues in common sequence conserved regions. And the phosphatases I and II can be correctly identified together by the structure-based PTP sequence motif from SWISS-PROT and TrEBML databases. The results show that the correct rates of identification are over 98%. This is the first time to identify PTP I and II together by this motif.
ISSN:2095-9273
2095-9281
DOI:10.1360/02tb9304