O-20 Cohort study of workers in the UK glass-reinforced plastics manufacturing industry

IntroductionPotentially high occupational exposures to styrene occur, largely in the absence of other chemicals, in the manufacture of glass-reinforced products. Styrene is also present in air pollution and tobacco smoke. The Health and Safety Executive’s (HSE) styrene cohort was previously included...

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Published in:Occupational and environmental medicine (London, England) England), 2023-03, Vol.80 (Suppl 1), p.A66-A67
Main Authors: McElvenny, Damien, Mueller, Will, Vries, Yvette Christopher-de, Sleeuwenhoek, Anne, Basinas, Ioannis, Tongeren, Martie van, Darnton, Lucy
Format: Article
Language:English
Subjects:
Abstracts
Air pollution
Cancer
Carcinogenicity
Carcinogens
Cohort analysis
Exposure
Glass fiber reinforced plastics
Manufacturing industry
Metabolites
Occupational health
Reinforced plastics
Styrene
Styrene-7,8-oxide
Styrenes
Tobacco
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Summary:IntroductionPotentially high occupational exposures to styrene occur, largely in the absence of other chemicals, in the manufacture of glass-reinforced products. Styrene is also present in air pollution and tobacco smoke. The Health and Safety Executive’s (HSE) styrene cohort was previously included in an international pooled cohort study coordinated by the International Agency for Research on Cancer (IARC). An update to this study is currently being coordinated by researchers at Aarhus University. This update will include an updated exposure assessment. In 2019, IARC published its updated evaluation of the carcinogenicity of styrene and styrene-7,8-oxide, a metabolite of styrene in humans. IARC concluded that both agents were probably carcinogenic to humans (Group 2A).The HSE cohort has never been separately analysed. It is only a small cohort (c 1800 participants), but it has long follow-up. It will contribute to the updated international study. Primary interest is in haematopoietic cancers, although other cancer sites such as oesophagus, nose and nasal cavities and lung are of interest too.Materials and MethodsResearch governance clearances were obtained from NHS Ethics, HRA Confidentiality Advisory Group and NHS Digital IGARD. Work is currently underway to obtain mortality and cancer registration data for the cohort. The intention is to produce SMRs and SIRs and, where sufficient number of events allow, subanalyses including by cumulative exposure will be undertaken.Results & ConclusionThe international study will be statistically the most powerful study to have examined the carcinogenicity of styrene to date. As well as cohorts from the UK, the updated study will include cohorts from Denmark, Finland, Italy, Norway, Sweden and the USA.
ISSN:1351-0711
1470-7926
DOI:10.1136/OEM-2023-EPICOH.163