Relationship between total antioxidant capacity and the severity of coronary artery disease

Objectives: It was known that oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease. The aim of this study is to evaluate the relationship between coronary artery disease and total antioxidant status, oxidative stress index. Materials and methods: The stu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical and experimental investigations 2012-03, Vol.3 (1), p.22
Main Authors: Aydın, Murat, Selcoki, Yusuf, Nazlı, Yunus, Yalçın, Kadir Serkan, Canbal, Metin, Demirçelik, Bora, Yiğitoğlu, Ramazan, Eryonucu, Beyhan
Format: Article
Language:English
Subjects:
Atherosclerosis
Cardiovascular disease
Coronary vessels
Oxidative stress
Vein & artery diseases
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: It was known that oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease. The aim of this study is to evaluate the relationship between coronary artery disease and total antioxidant status, oxidative stress index. Materials and methods: The study group consisted of 87 consecutive patients who were hospitalized for coronary angiography. Plasma total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and oxidative stress index (OSI) was calculated. Results: The TAC values increased statistically significant in the four tertile compared with the first tertile (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) and the TOS values decreased non- significantly in the four tertile ( 5.2 ± 2.8 vs 7.2 ± 5.4 µmol H2O2 Eq/l) as compared to the patients in the first tertile. According to the number of diseased vessels, plasma oxidative characteristics did not differ between the three groups. Conclusions: Plasma TAC levels increased in subjects with coronary atherosclerosis and severity of coronary atherosclerosis is related with TAC.
ISSN:1309-6621
1309-6621
DOI:10.5799/ahinjs.01.2012.01.0105