Increased Sister Chromatid Exchanges in Patients with Gastrointestinal Cancers and in their First-Degree Relatives

Gastrointestinal Cancers (GICs) are the most important causes of mortality and morbidity in industrialized world. Sister chromatid exchange (SCE), as an index of chromosomal instability, involves cancer. The aim of this study is to determine whether SCE frequency is a heritable factor for GIC or not...

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Bibliographic Details
Published in:Electronic journal of general medicine 2014-04, Vol.11 (2), p.94
Main Authors: Turgut, Taner, Yaşar, Mehmet, Yaykaşlı, Kürşat Oğuz, Ertaş, Ertuğrul, Sılan, Fatma
Format: Article
Language:English
Subjects:
Epigenetics
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Summary:Gastrointestinal Cancers (GICs) are the most important causes of mortality and morbidity in industrialized world. Sister chromatid exchange (SCE), as an index of chromosomal instability, involves cancer. The aim of this study is to determine whether SCE frequency is a heritable factor for GIC or not. The study groups consisted of 15 gastrointestinal carcinoma patients, 13 patient relatives and 15 healthy subjects as the control group. After collection of 2 ml peripheral blood, lymphocytes were cultured for 3 days and sister chromatid exchange (SCE), mitotic index, and replication index were analyzed. SCE was significantly increased (p
ISSN:2516-3507
2516-3507
DOI:10.15197/sabad.1.11.46