Biocompatibility Analysis of GelMa Hydrogel and Silastic RTV 9161 Elastomer for Encapsulation of Electronic Devices for Subdermal Implantable Devices

The natural differences between human-made electronics and biological tissues constitute a huge challenge in materials and the manufacturing of next-generation bioelectronics. As such, we performed a series of consecutive experiments for testing the biofunctionality and biocompatibility for device i...

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Published in:Coatings (Basel) 2023-01, Vol.13 (1), p.19
Main Authors: Dragomir, David Catalin, Carbunaru, Vlad, Moldovan, Carmen Aura, Lascar, Ioan, Dontu, Octavian, Ristoiu, Violeta, Gheorghe, Roxana, Oproiu, Ana Maria, Firtat, Bogdan, Franti, Eduard, Dascalu, Monica, Neagu, Tiberiu Paul, Enescu, Dan Mircea, Ionescu, Octavian, Ion, Marian, Mihailescu, Carmen, Costea, Ruxandra, Gonciarov, Magda, Ionescu, Gabriela, Dumitru, Adrian, Minca, Anca, Niculae, Catalin, Raita, Stefania, Rosca, Ioana, Lazarescu, Sorin, Stoica, Cristian, Teleanu, Raluca Ioana, Teleanu, Daniel Mihai
Format: Article
Language:English
Subjects:
Biocompatibility
Bioelectricity
Biomechanics
Coating
Dielectric properties
Elastomers
Electronic devices
Electronics
Hydrogels
Light
Medical research
Physical properties
Printing
Tissues
Voltage regulators
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Summary:The natural differences between human-made electronics and biological tissues constitute a huge challenge in materials and the manufacturing of next-generation bioelectronics. As such, we performed a series of consecutive experiments for testing the biofunctionality and biocompatibility for device implantation, by changing the exterior chemical and physical properties of electronics coating it with silicone or hydrogels. In this article, we present a comparison of the main characteristics of an electronic device coated with either silicone or hydrogel (GelMa). The coating was performed with a bioprinter for accurate silicone and hydrogel deposition around different electronic chips (Step-Down Voltage Regulator U3V15F5 from Pololu Corporation). The results demonstrate that the hydrogel coating presents an augmented biomechanical and biochemical interface and superior biocompatibility, lowers foreign body response, and considerably extends the capabilities for bioelectronic applications.
ISSN:2079-6412
2079-6412
DOI:10.3390/coatings13010019