Indium chloride catalysed benzyl bromination using continuous flow technology

This report describes the development of a water-tolerant green catalyst for benzyl bromination. The catalyst, indium chloride, exhibits high catalytic activity with a variety of toluene derivatives in continuous flow. Good yields (5977%) were obtained in all the cases. Improved selectivity was obse...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2023-01, Vol.21 (3), p.58-513
Main Authors: Thankappan, Hajeeth, Burke, Conor, Glennon, Brian
Format: Article
Language:English
Subjects:
Bromination
Catalysts
Catalytic activity
Chlorides
Continuous flow
Halogenation
Indium
Selectivity
Toluene
Water
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Summary:This report describes the development of a water-tolerant green catalyst for benzyl bromination. The catalyst, indium chloride, exhibits high catalytic activity with a variety of toluene derivatives in continuous flow. Good yields (5977%) were obtained in all the cases. Improved selectivity was observed under flow conditions, when compared to batch operation. An efficient continuous-flow synthesis of benzyl bromide with excellent selectivity using InCl 3 as a green catalyst is described. The flow process employed is readily scalable for large-scale manufacture.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob01840c