Strong and Tough Supramolecular Microneedle Patches with Ultrafast Dissolution and Rapid‐Onset Capabilities

Dissolving microneedle (DMN) patches are emerging as a minimally invasive and efficient transdermal drug delivery platform. Generally, noncrystalline, water‐soluble, and high‐molecular‐weight polymers are employed in DMNs because their sufficient intermolecular interactions can endow the DMNs with n...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2022-12, Vol.34 (51), p.e2207832-n/a
Main Authors: Wang, Hua, Fu, Yangxue, Mao, Jinzhu, Jiang, Hao, Du, Shuo, Liu, Pei, Tao, Juan, Zhang, Lianbin, Zhu, Jintao
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Bonding strength
Chain entanglement
cyclodextrin
Cyclodextrins
Dissolution
dissolving microneedles
Drug Delivery Systems
Entanglement
Ibuprofen
Materials science
mechanical robustness
Mice
Microinjections
Needles
Nonsteroidal anti-inflammatory drugs
Payloads
Polymers - chemistry
Rhodamine
Robustness
Skin
Solubility
supramolecular polymers
transdermal drug delivery
Xylene
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Summary:Dissolving microneedle (DMN) patches are emerging as a minimally invasive and efficient transdermal drug delivery platform. Generally, noncrystalline, water‐soluble, and high‐molecular‐weight polymers are employed in DMNs because their sufficient intermolecular interactions can endow the DMNs with necessary mechanical strength and toughness. However, high viscosity and heavy chain entanglement of polymer solutions greatly hinder processing and dissolution of polymeric DMNs. Here, a strong and tough supramolecular DMN patch made of highly water‐soluble cyclodextrin (CD) derivatives is described. Due to the synergy of multiple supramolecular interactions, the CD DMN patch exhibits robust mechanical strength outperforming the state‐of‐the‐art polymeric DMNs. The CD DMN displays ultrafast dissolution (
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202207832