Synthesis of new conjugates of 6-thiopurine and thioguanine with (S)-glutamic acid

We have developed an efficient method for the synthesis of 6-thiopurine and thioguanine conjugates containing a ( S )-glutamic acid residue, which is based on the reaction of 6-thio derivatives of purine with di- tert -butyl N -chloroacetyl-( S )-glutamate and subsequent hydrolysis of the ester grou...

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Bibliographic Details
Published in:Russian chemical bulletin 2022-11, Vol.71 (11), p.2426-2430
Main Authors: Telegina, A. A., Gruzdev, D. A., Levit, G. L., Krasnov, V. P.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Conjugates
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Glutamic acid
Inorganic Chemistry
Organic Chemistry
Synthesis
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Summary:We have developed an efficient method for the synthesis of 6-thiopurine and thioguanine conjugates containing a ( S )-glutamic acid residue, which is based on the reaction of 6-thio derivatives of purine with di- tert -butyl N -chloroacetyl-( S )-glutamate and subsequent hydrolysis of the ester groups.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-022-3670-4