Smart polymer grafted silica based drug delivery systems

Smart polymers are a special class of polymers, which respond to the various external stimuli by changing their properties. Recent developments in synthetic polymer chemistry have provided the possibility of designing and synthesis of various new stimuli‐responsive polymers. These stimuli‐responsive...

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Bibliographic Details
Published in:Polymers for advanced technologies 2023-01, Vol.34 (1), p.24-43
Main Authors: Shah, Ishika U., Jadhav, Sushilkumar A., Belekar, Vedika M., Patil, Pramod S.
Format: Article
Language:English
Subjects:
Chemical synthesis
drug delivery system
Drug delivery systems
Grafting
Nanomaterials
Nanoparticles
Polymer chemistry
Polymers
silica
Silicon dioxide
smart polymers
Stimuli
stimuli‐responsive polymers
stimulus
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Summary:Smart polymers are a special class of polymers, which respond to the various external stimuli by changing their properties. Recent developments in synthetic polymer chemistry have provided the possibility of designing and synthesis of various new stimuli‐responsive polymers. These stimuli‐responsive polymers can be used to prepare smart drug delivery systems (DDS) by grafting them on various nanomaterials. The main aim of this review is to present collective information on various stimuli‐responsive polymers grafted on silica nanoparticles for the preparation of smart DDS. The stimuli covered are pH, temperature, redox, reactive oxygen species (ROS), glucose concentration, enzymes, magnetic field, and so forth. The structures of various stimuli‐responsive polymers are shown with their relevance to the preparation of smart DDS. The crucial roles of macromolecular design and synthesis of smart polymers in the development of stimuli‐responsive DDS are discussed with examples from literature and the challenges that still exist in this area of research are presented.
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.5890