Bleomycin-Induced Fulminant Hyperpyrexia: A Report of Two Cases and Review of Literature

Bleomycin is a commonly used cytotoxic agent that has proven its efficacy over the years. Though a common part of many protocols targeting lymphomas and germ cell tumors, it does have some serious adverse effects. Bleomycin is notorious for pulmonary toxicity and very rarely may cause fulminant hype...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-09, Vol.14 (9)
Main Authors: Jhatial, Mussadique Ali, Bin Naeem, Sameen, Abbas, Mansoor, Baloch, Naqib Ullah, Bokhari, Syed W, Ahsan, Bushra, Ahmad, Usman, Masood Sheikh, Rizwan
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Blood pressure
Case reports
Chemotherapy
Disease
Drug dosages
Enzymes
Fever
Heart rate
Hemoglobin
Hepatitis C
Intensive care
Lymphoma
Medical imaging
Pleural effusion
Tomography
Ultrasonic imaging
Ventilators
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Summary:Bleomycin is a commonly used cytotoxic agent that has proven its efficacy over the years. Though a common part of many protocols targeting lymphomas and germ cell tumors, it does have some serious adverse effects. Bleomycin is notorious for pulmonary toxicity and very rarely may cause fulminant hyperpyrexia. We describe two cases of classical Hodgkin’s lymphoma (cHL) developing acute fulminant hyperpyrexia after administration of the first dose of bleomycin as part of chemotherapy protocol. This is a rare adverse reaction that closely mimics anaphylaxis and has an unpredictable and possibly fatal course. Health care professionals involved in the administration of chemotherapy need to be very vigilant in monitoring for symptoms of this reaction.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.29785