Impact of obstructive sleep apnea on platelet activation and development of silent brain infarctions

BackgroundObstructive sleep apnea (OSA) is a unique potent predictor for stroke compared to other predictors. By aiding in the adherence of leukocytes and platelets, soluble P-selectin (sP-selectin) contributes to the development of ischemic stroke. The objective of this study was to investigate the...

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Bibliographic Details
Published in:The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Psychiatry and Neurosurgery, 2022-11, Vol.58 (1), p.1-8
Main Authors: Abd El-Razek, Reda, Abou Hagar, Ahmed, Orabi, Marwa, Moawad, Sabry, El-Samahy, Mohamed
Format: Article
Language:English
Subjects:
Obstructive sleep apnea
Silent brain infarctions
Sleep apnea
Soluble P-selectin
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Summary:BackgroundObstructive sleep apnea (OSA) is a unique potent predictor for stroke compared to other predictors. By aiding in the adherence of leukocytes and platelets, soluble P-selectin (sP-selectin) contributes to the development of ischemic stroke. The objective of this study was to investigate the independent impact of OSA on platelet activation and development of silent brain infarction. Twenty-four OSA patients and 24 controls were studied in a case–control study, who underwent one-night polysomnography, magnetic resonance imaging for evaluation of silent brain infarctions (SBI), measurement of serum (sP-selectin) levels for assessment of increased platelet activation and C-reactive protein (CRP) serum levels.ResultsOut of 24 patients, 5 (20.8%) had mild OSA and 8 (33.3%) had moderate and 11 (45.8%) had severe OSA. Serum levels of sP-selectin were statistically significantly higher in moderate and severe groups (p 
ISSN:1110-1083
1687-8329
DOI:10.1186/s41983-022-00575-6