ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of molecules with oxidizing properties known as ROS. Despite those molecules being implied negatively in aging and numerous diseases, their key role in cellular signaling is evident. ROS control several biological...

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Published in:Oxidative medicine and cellular longevity 2022-10, Vol.2022, p.1-23
Main Authors: de Almeida, Arthur José Pontes Oliveira, de Oliveira, Júlio César Pinheiro Lúcio, da Silva Pontes, Larisse Virgolino, de Souza Júnior, Javanyr Frederico, Gonçalves, Tays Amanda Felisberto, Dantas, Sabine Helena, de Almeida Feitosa, Mathania Silva, Silva, Antonia Oliveira, de Medeiros, Isac Almeida
Format: Article
Language:English
Subjects:
Cytochrome
Dehydrogenases
Enzymes
Free radicals
Metabolism
Mitochondria
Mitochondrial DNA
Nitrogen dioxide
Oxidative stress
Physiology
Proteins
Review
Theories of aging
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Summary:Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of molecules with oxidizing properties known as ROS. Despite those molecules being implied negatively in aging and numerous diseases, their key role in cellular signaling is evident. ROS control several biological processes such as inflammation, proliferation, and cell death. The redox signaling underlying these cellular events is one characteristic of the new generation of scientists aimed at defining the role of ROS in the cellular environment. The control of redox potential, which includes the balance of the sources of ROS and the antioxidant system, implies an important target for understanding the cells’ fate derived from redox signaling. In this review, we summarized the chemical, the redox balance, the signaling, and the implications of ROS in biological aging.
ISSN:1942-0900
1942-0994
DOI:10.1155/2022/1225578