The Global Prevalence of Peptic Ulcer in the World: a Systematic Review and Meta-analysis

Peptic ulcer is one of the most common diseases of the gastrointestinal tract, which, if not addressed, can increase mortality in different communities. As regards the results of various studies around the world that have reported different prevalence, the aim of this study was to determine the over...

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Bibliographic Details
Published in:Indian journal of surgery 2022-10, Vol.84 (5), p.913-921
Main Authors: Salari, Nader, Darvishi, Niloofar, Shohaimi, Shamarina, Bartina, Yalda, Ahmadipanah, Melika, Salari, Hamid Reza, Mohammadi, Masoud
Format: Article
Language:English
Subjects:
Analysis
Cardiac Surgery
Gastrointestinal system
Health aspects
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Meta-analysis
Mortality
Neurosurgery
Online databases
Pediatric Surgery
Peptic ulcer
Plastic Surgery
Review Article
Surgery
Systematic review
Thoracic Surgery
Ulcers
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Summary:Peptic ulcer is one of the most common diseases of the gastrointestinal tract, which, if not addressed, can increase mortality in different communities. As regards the results of various studies around the world that have reported different prevalence, the aim of this study was to determine the overall prevalence of peptic ulcer in the world through systematic review and meta-analysis. In this systematic review and meta-analysis, articles focused on the prevalence of peptic ulcer were searched in the Scopus, Embase, Web of Science, PubMed and Science Direct, Google Scholar, Magiran, Irandoc, and Scientific Information Database databases, without time limit until April 2020. To analyze the eligible studies, the random effects model was used, and the heterogeneity of the studies was investigated using the I 2 index. The prevalence of peptic ulcer in the world in 21 studies with total sample size 788,525 in age range of 17–82 years was obtained as 8.4% (95% CI 5–13.7). According to the results from meta regression, the prevalence of peptic ulcer in the world decreased with an increase in sample size and increased with an increase in study years and age of participants in the study of the prevalence of peptic ulcer in the world. It was found that these differences were also statistically significant ( P  
ISSN:0972-2068
0973-9793
DOI:10.1007/s12262-021-03189-z