Marker-assisted selection of dairy cows for β-casein gene A2 variant

Many studies highlighted potential associations of β-casein A1 with specific human diseases and a minor digestibility of milk, due to the bioactive peptide β-casomorphin 7 (BCM-7) release during digestion. Conversely, the ancestral β-casein A2 variant seems to be a favorable trait because it is not...

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Bibliographic Details
Published in:Italian journal of food science 2022-01, Vol.34 (2), p.21-27
Main Authors: Sebastiani, Carla, Arcangeli, Chiara, Torricelli, Martina, Ciullo, Marcella, D’avino, Nicoletta, Cinti, Giulia, Fisichella, Stefano, Biagetti, Massimo
Format: Article
Language:English
Subjects:
Amino acids
Casein
Dairy cattle
Dairy products
Digestibility
DNA methylation
Genomes
Lactose
Marker-assisted selection
Milk
Offspring
Peptides
Proteins
Semen
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Summary:Many studies highlighted potential associations of β-casein A1 with specific human diseases and a minor digestibility of milk, due to the bioactive peptide β-casomorphin 7 (BCM-7) release during digestion. Conversely, the ancestral β-casein A2 variant seems to be a favorable trait because it is not associated with BMC-7 release. The aim of this work was to evaluate frequencies of β-casein variants in offspring of previously genotyped cows inseminated with A2 homozygous semen. The frequency of the A2/A2 animals has almost doubled from 37 to 69%. These are encouraging results with the perspective of reaching the goal of producing A2 milk.
ISSN:1120-1770
1120-1770
2239-5687
DOI:10.15586/ijfs.v34i2.2178