Loading…
Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application
The aim of the study was to investigate the uses of hydrophilic polymers i.e. Methocel K4M and Carbomer 971 to develop a gastroretentive floating drug delivery system containing Carbamazipine as a model drug. The effect of the polymers was evaluated in terms of physical characteristics, swelling pro...
Saved in:
Published in: | Journal of Research in Pharmacy 2017-01, Vol.21 (24530), p.59-66 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The aim of the study was to investigate the uses of hydrophilic polymers i.e. Methocel K4M and Carbomer 971 to develop a gastroretentive floating drug delivery system containing Carbamazipine as a model drug. The effect of the polymers was evaluated in terms of physical characteristics, swelling properties, floating behavior and drug release profile. Floating lag time was found to be 4-136 sec and total floating time was 6-18 h depending on the formulations. Drug release was studied for 8 h. Simulated drug release pattern in different kinetic model suggests that the mechanism controlling of the drug release from all formulations was the anomalous or non-Fickian. Along with more swelling capacity, carbopol 971 was able to retard the drug release more effectively than that of Methocel K4M based matrix. |
---|---|
ISSN: | 1309-0801 2630-6344 1309-0801 2630-6344 |
DOI: | 10.12991/marupj.259882 |