5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents

This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds (2a and 2c) we...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Research in Pharmacy 2020-01, Vol.24 (1), p.1-8
Main Authors: MONCOL, Jan, KRISHNA, Vagolu Siva, SRIRAM, Dharmarajan, ÖZADALI-SARI, Keriman, EKİNCİ, Ahmet Serhat
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds (2a and 2c) were determined by the single-crystal X-ray diffraction study. Among the target compounds, 2-(4-ethoxyphenyl)-5-methyl-3-(phenylamino)thiazolidin-4-one (2g) was promising with a minimum inhibitory concentration of 12.5 μg/mL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity.
ISSN:2630-6344
2630-6344
DOI:10.35333/jrp.2020.110