Recent advances in the transition metal-free synthesis of heterocycles from α,β-unsaturated ketones

Heterocyclic compounds are an inevitable part of our life. These important classes of molecules have a wide range of applications starting from life-sustaining drugs to agrochemicals. Numerous methods, including metal and non-metal mediated protocols, are documented to synthesise complex and straigh...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2022-09, Vol.9 (19), p.5306-5357
Main Authors: Ashitha, Kizhakkan Thiruthi, Ajay Krishna M S, Basavaraja, D, Somappa, Sasidhar B
Format: Article
Language:English
Subjects:
Agrochemicals
Carbonyl compounds
Carbonyls
Catalysts
Heterocyclic compounds
Ketones
Metals
Organic chemistry
Substrates
Toxicity
Transition metals
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Summary:Heterocyclic compounds are an inevitable part of our life. These important classes of molecules have a wide range of applications starting from life-sustaining drugs to agrochemicals. Numerous methods, including metal and non-metal mediated protocols, are documented to synthesise complex and straightforward heterocyclic entities. The metal-free protocols have more significance over the metal-catalyzed ones when the toxicity associated with the metal catalyst is considered. On the other hand, α,β-unsaturated ketones are essential building blocks in synthetic organic chemistry. The presence of multiple reaction sites makes conjugated carbonyls suitable substrates for constructing a vast array of heterocycles and carbocycles. Herein, the review's primary focus is to highlight the transition metal-free methodologies developed for synthesising various heterocyclic compounds by utilising α,β-unsaturated ketones as valuable synthons during the period of 2009 to 2020.
ISSN:2052-4110
2052-4110
DOI:10.1039/d2qo00278g