Spectrophotometric Determination of Azorubine and Ponceau 4R in Pharmaceutical Preparations Using Micellar Extraction

We compared the capabilities of extraction systems based on polyoxyethylated alkylphenols Triton X-100 and OP-10 for extracting synthetic food dyes Azorubine and Ponceau 4R in different phase separation modes: cloud-point temperature and salting-out with sodium sulfate. The effects of temperature, p...

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Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2022-09, Vol.77 (9), p.1073-1081
Main Authors: Shestopalova, N. B., Fomina, Yu. A., Chernova, R. K.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Composition
Drugs
Dyes
Extraction (Chemistry)
Extraction procedures
Methods
Phase equilibria
Phase separation
Salting
Sodium sulfate
Spectrophotometry
Temperature effects
Testing
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Summary:We compared the capabilities of extraction systems based on polyoxyethylated alkylphenols Triton X-100 and OP-10 for extracting synthetic food dyes Azorubine and Ponceau 4R in different phase separation modes: cloud-point temperature and salting-out with sodium sulfate. The effects of temperature, pH, surfactant, and electrolyte concentrations on the physicochemical characteristics of the micellar phase and the rate for reaching phase equilibrium are studied. A simple and effective extraction procedure with salting-out is proposed. The optimal conditions for the maximum extraction of the dyes ( R > 98%) were determined in various modes: at the cloud point for Azorubine and upon salting-out for Ponceau 4R. Procedures have been developed for the spectrophotometric determination of analytes in syrups and lozenges with micellar-extraction preconcentration.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934822080135