A comprehensive study of the structure and piezoelectric response of biodegradable polyhydroxybutyrate-based films for tissue engineering applications

The results of comprehensive research on the thermal behavior and molecular and crystalline structures of poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB-HV) films of different thicknesses, their molecular weights (Mw) and 3-hydroxyvalerate (3-HV) contents are rep...

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Bibliographic Details
Published in:Polymer journal 2022-10, Vol.54 (10), p.1225-1236
Main Authors: Chernozem, Roman V., Pariy, Igor O., Pryadko, Artem, Bonartsev, Anton P., Voinova, Vera V., Zhuikov, Vsevolod A., Makhina, Tatiana K., Bonartseva, Garina A., Shaitan, Konstantin V., Shvartsman, Vladimir V., Lupascu, Doru C., Romanyuk, Konstantin N., Kholkin, Andrei L., Surmenev, Roman A., Surmeneva, Maria A.
Format: Article
Language:English
Subjects:
Anisotropy
Biodegradability
Crystal structure
Crystallinity
Crystallites
Degree of crystallinity
Domains
Film thickness
Melt temperature
Molecular weight
Piezoelectricity
Polyhydroxybutyrate
Thermodynamic properties
Tissue engineering
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Summary:The results of comprehensive research on the thermal behavior and molecular and crystalline structures of poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB-HV) films of different thicknesses, their molecular weights (Mw) and 3-hydroxyvalerate (3-HV) contents are reported. Increasing film thickness from 30 to 100 µm resulted in an isotropic crystal orientation, reducing the crystallite size of the orthorhombic α-phase in the b direction from 22 to 17 nm and increasing the degree of crystallinity of the PHB films without affecting their thermal behavior. Furthermore, despite resulting in the same degree of crystallinity and roughness, an ~8-fold decrease in PHB Mw from 803 kDa to 102 kDa resulted in a decreased number of piezoactive domains. The addition of 5.9% 3-HV resulted in anisotropy in the PHB crystalline structure and increased D(020) from 19 nm to 24 nm. Additionally, a further increase in the 3-HV content to 17.5% in the PHB-HV films led to a decrease in the melting temperature and a decrease in the degree of crystallinity from 57% to 23%, which resulted in the absence of local piezoresponse. Notably, the decrease in the Mw of PHB-HV (~17%) from 1177 kDa to 756 kDa resulted in an increase in the degree of crystallinity from 23% to 32%. Moreover, the PHB-HV films became smoother with increasing 3-HV content.The results of comprehensive research on the thermal behavior, molecular and crystalline structures of poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB-HV) films of different thicknesses, their molecular weights (Mw) and 3-hydroxyvalerate (3-HV) contents are reported. The film thickness affects the PHB film crystalline structure and crystallinity. A decrease in Mw leads to a smaller number of piezoactive domains in PHB films. The addition of HV significantly reduces the crystallinity and piezoresponse of PHB films. A decrease in Mw results in the increased crystallinity of PHB-HV films.
ISSN:0032-3896
1349-0540
DOI:10.1038/s41428-022-00662-8