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Europium-Containing Conjugate for Photodynamic Therapy of Malignant Neoplasms

The rapid growth in the number of oncological diseases justifies the need to create new therapeutic agents and methods. Photodynamic therapy has a wide range of treatments for superficial diseases due to the inability to penetrate more than 3 mm of laser light into tissues. The aim of the study was...

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Bibliographic Details
Published in:Russian journal of inorganic chemistry 2022-09, Vol.67 (9), p.1361-1367
Main Authors: Shevchenko, O. V., Plekhova, N. G., Medkov, M. A., Parichuk, K. A., Apanasevich, V. I., Tananaev, I. G., Yudakov, A. A., Lukyanov, P. A.
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Language:English
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Summary:The rapid growth in the number of oncological diseases justifies the need to create new therapeutic agents and methods. Photodynamic therapy has a wide range of treatments for superficial diseases due to the inability to penetrate more than 3 mm of laser light into tissues. The aim of the study was to characterize the physicochemical properties of a new PEI-E6-DTPA-FA-Eu molecular conjugate based on the europium-modified Сhlorin E6 photosensitizer and to evaluate its phototoxic effect on Ehrlich ascitic tumor cells. It has been established that under 5-minute irradiation with a wavelength of 645 nm and an energy of 6 J/cm 2 , the synthesized molecular conjugate PEI-E6-DTPA-FA-Eu generates reactive oxygen species 5.1 times more intensively than free Chlorin E6. On the 4th day after photodynamic exposure with PEI-E6-DTPA-FA-Eu, the cell death rate was 75%, while with Chlorin Е6 it was only 24%.
ISSN:0036-0236
1531-8613
DOI:10.1134/S003602362209011X