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Europium-Containing Conjugate for Photodynamic Therapy of Malignant Neoplasms
The rapid growth in the number of oncological diseases justifies the need to create new therapeutic agents and methods. Photodynamic therapy has a wide range of treatments for superficial diseases due to the inability to penetrate more than 3 mm of laser light into tissues. The aim of the study was...
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Published in: | Russian journal of inorganic chemistry 2022-09, Vol.67 (9), p.1361-1367 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The rapid growth in the number of oncological diseases justifies the need to create new therapeutic agents and methods. Photodynamic therapy has a wide range of treatments for superficial diseases due to the inability to penetrate more than 3 mm of laser light into tissues. The aim of the study was to characterize the physicochemical properties of a new PEI-E6-DTPA-FA-Eu molecular conjugate based on the europium-modified Сhlorin E6 photosensitizer and to evaluate its phototoxic effect on Ehrlich ascitic tumor cells. It has been established that under 5-minute irradiation with a wavelength of 645 nm and an energy of 6 J/cm
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, the synthesized molecular conjugate PEI-E6-DTPA-FA-Eu generates reactive oxygen species 5.1 times more intensively than free Chlorin E6. On the 4th day after photodynamic exposure with PEI-E6-DTPA-FA-Eu, the cell death rate was 75%, while with Chlorin Е6 it was only 24%. |
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ISSN: | 0036-0236 1531-8613 |
DOI: | 10.1134/S003602362209011X |