False-positive Xpert® Xpress SARS-CoV-2 assay in an emergency room and trauma center

Objectives:To review reports false-positive Xpert results in an emergency room and trauma center.Methods:Patients’ data with false-positive Xpert results from November 2020 to February 2022 at Pusan National University Hospital, Busan, Republic of Korea, were extracted from the electronic medical re...

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Bibliographic Details
Published in:Saudi medical journal 2022-08, Vol.43 (8), p.965-970
Main Authors: Kim, Hyerim, Jeon Soeun, Lee Sun Hack, Hyun-Su, Ri, Hyeon-Jeong, Lee, Jeong-Min, Hong, Paek Sung In
Format: Article
Language:English
Subjects:
Accuracy
Bioassays
COVID-19 diagnostic tests
Emergency medical care
Severe acute respiratory syndrome coronavirus 2
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Summary:Objectives:To review reports false-positive Xpert results in an emergency room and trauma center.Methods:Patients’ data with false-positive Xpert results from November 2020 to February 2022 at Pusan National University Hospital, Busan, Republic of Korea, were extracted from the electronic medical records.Results:The positive predictive value of Xpert was 40%. Of the 12 patients with false-positive results, 5 (41.7%) were re-positives (such as, patients recovered from coronavirus disease-19 [COVID-19]), and 4 (33.3%) had head or facial trauma. Two out of 4 head or facial trauma cases had documented sample contamination with blood.Conclusion:We found a high incidence of false-positive Xpert results among patients who recovered from COVID-19 and those with head or facial injury. Careful history taking for COVID-19 and physical examination of the sample collection site is essential before Xpert analysis.
ISSN:0379-5284
1658-3175
DOI:10.15537/smj.2022.43.8.20220317