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Modification of Pyrroloisoquinolines with 2‐Bromoketones and Dimethyl Sulfoxide through Bromination
Bromination of various dihydropyrrolo[2,1‐a]isoquinolines have been reached in moderate to good yields by the use of alkylacyl bromides and dimethyl sulfoxide as brominating reagent. Other N‐containing heterocycles of interest such as pyrrolo[2,1‐a]isoquinoline and multisubstituted pyrroles can also...
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Published in: | Asian journal of organic chemistry 2022-08, Vol.11 (8), p.n/a |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Bromination of various dihydropyrrolo[2,1‐a]isoquinolines have been reached in moderate to good yields by the use of alkylacyl bromides and dimethyl sulfoxide as brominating reagent. Other N‐containing heterocycles of interest such as pyrrolo[2,1‐a]isoquinoline and multisubstituted pyrroles can also be brominated successfully under the current reaction system. Distinct reactivities between alkylacyl and arylacyl bromides resulting in bromination and dicarbonylation respectively have been investigated.
Bromination of various dihydropyrrolo[2,1‐a]isoquinolines and interesting N‐heterocycles has been achieved in moderate to good yields by the use of 2‐bromo‐1‐cyclopropylethanone and dimethyl sulfoxide as brominating reagents. |
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ISSN: | 2193-5807 2193-5815 |
DOI: | 10.1002/ajoc.202200342 |