Arthrospira platensis nanoparticles defeat against diabetes‐induced testicular injury in rat targeting, oxidative, apoptotic, and steroidogenesis pathways

Varieties of studies have been used to investigate the health benefits of Spirulina (Arthrospira platensis); however, more research is needed to examine if its nano form may be utilized to treat or prevent several chronic diseases. So, we designed this study to explore the effect and the cellular in...

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Bibliographic Details
Published in:Andrologia 2022-09, Vol.54 (8), p.e14456-n/a
Main Authors: Shaman, Amani Ali, Zidan, Nahla S., Atteia, Hebatallah H., Alalawy, Adel I., Alzahrani, Sharifa, AlBishi, Laila A., Helal, Azza I., Braiji, Shafiqah H., Farrag, Foad, Shukry, Mustafa, Sakran, Mohamed I.
Format: Article
Language:English
Subjects:
Accessory gland
Antioxidants
Apoptosis
Arthrospira platensis
Body weight
Chronic illnesses
Diabetes
Diabetes mellitus
diabetic rat
Follicle-stimulating hormone
Gene expression
Gene regulation
Luteinizing hormone
Nanoparticles
Nitric oxide
NSP
Oral administration
Oxidative stress
Rodents
Steroidogenesis
Superoxide dismutase
Testes
testicular injury
Testosterone
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Summary:Varieties of studies have been used to investigate the health benefits of Spirulina (Arthrospira platensis); however, more research is needed to examine if its nano form may be utilized to treat or prevent several chronic diseases. So, we designed this study to explore the effect and the cellular intracellular mechanisms by which Arthrospira platensis Nanoparticles (NSP) alleviates the testicular injury induced by diabetes in male Wistar rats. Eighty Wistar male rats (n = 80) were randomly allocated into eight groups. Group 1 is untreated rats (control), Group 2 including STZ‐induced diabetic rats with 65 mg/kg body weight STZ (STZ‐diabetic), Group 3–5: including diabetic rats treated with NSP1, NSP2, and NSP3 at 0.25, 0.5, and 1 mg/kg body weight, respectively, once daily orally by the aid of gastric gavage for 12 consecutive weeks and groups 6–8 include normal rats received NSP (0.25, 0.5, and 1 mg/kg body weight once daily orally. The identical volume of normal saline was injected into both control and diabetic rats. After 12 weeks of diabetes induction, the rats were killed. According to our findings, NSP administration to diabetic rats enhances the total body weight and the weight of testes and accessory glands; in addition, NSP significantly reduced nitric oxide and malondialdehyde in testicular tissue improved sperm parameters. Intriguingly, it raises testicular GSH and SOD activity by a significant amount (p 
ISSN:0303-4569
1439-0272
DOI:10.1111/and.14456