Chemical constituents from the Streptomyces morookaensis strain Sm4-1986

Three new compounds, including 6-methoxy-3,4,5,7-tetramethylisochromane-3,8-diol (1), 3,4,5,7-tetramethylisochromane-3,6,8-triol (2), streptimidone derivative (3), along with ten known compounds (4-13) were isolated from the Streptomyces morookaensis strain Sm4-1986. Their chemical structures were e...

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Bibliographic Details
Published in:Natural product research 2022-07, Vol.36 (14), p.3681-3688
Main Authors: Wu, Gui-Yun, Zhu, Zhi-Yan, Zhang, Xiao, Wang, Miao-Miao, Li, Jian-Xiong, Hu, Ying-Jie, Tan, Hai-Bo
Format: Article
Language:English
Subjects:
antibacterial activities
Antibacterial activity
cytotoxicities
Drug resistance
Methicillin
NMR
Nuclear magnetic resonance
Streptomyces
Streptomyces morookaensis
Tumor cell lines
Tumors
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Summary:Three new compounds, including 6-methoxy-3,4,5,7-tetramethylisochromane-3,8-diol (1), 3,4,5,7-tetramethylisochromane-3,6,8-triol (2), streptimidone derivative (3), along with ten known compounds (4-13) were isolated from the Streptomyces morookaensis strain Sm4-1986. Their chemical structures were established based on the information from UV, IR, NMR ( 1 H NMR, 13 C NMR, 1 H- 1 H COSY, HSQC, HMBC, NOESY), and mass spectroscopic. Moreover, all the isolated new compounds were evaluated for antibacterial activities (S. aureus, B. cereus, S. epidermids and methicillin-resistant S. aureus) and their cytotoxicities against MCF-7, A549, Hela tumor cell lines and Marc-145 normal cell line.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1881095