Age-Related Changes in the Functional Activity of ATP-Sensitive Potassium Channels in Rat Pial Arteries

Age-related changes in the contribution of ATP-sensitive potassium channels (K ATP ) to basal tone and acetylcholine (ACh)-mediated dilation of pial arterial vessels were studied in Wistar rats aged 4 and 18 months using intravital microphotography. A change in the contribution of K ATP channels to...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2022-03, Vol.58 (2), p.345-352
Main Author: Gorshkova, O. P.
Format: Article
Language:English
Subjects:
Aging
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Evolutionary Biology
Experimental Papers
Glibenclamide
Life Sciences
Pial artery
Potassium
Potassium channels
Vasodilation
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Summary:Age-related changes in the contribution of ATP-sensitive potassium channels (K ATP ) to basal tone and acetylcholine (ACh)-mediated dilation of pial arterial vessels were studied in Wistar rats aged 4 and 18 months using intravital microphotography. A change in the contribution of K ATP channels to the maintenance of basal tone was assessed by the change in the number of vessels constricted in response to a K ATP channel blocker glibenclamide (10 µM). A change in the contribution of K ATP channels to vasodilation was assessed by comparing the number and degree of arterial dilation in response to ACh (10 –7 M, 5 min) before and after glibenclamide application. It was found that aging is accompanied by a decrease in the contribution of K ATP channels to basal tone of pial arteries. Moreover, the functional activity of K ATP channels and their contribution to vasodilation decreases with age, and in 18-month-old rats they are practically not involved in the dilatory response to ACh.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093022020041