Surrogates of the Left Ventricular Thrombus Resolution: A Retrospective Data Review

Objective: The left ventricular thrombus is one of the serious complications of ischemic cardiomyopathy. In this study, we aimed to search for the independent factors to predict the resolution of left ventricular thrombus. Methods: This retrospective study included all patients with coronary artery...

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Published in:Türk Kardiyoloji Derneği arşivi 2022-04, Vol.50 (3), p.168
Main Authors: Hosameldin Salah Shabib Ahmed, Ede, Hüseyin, Ahmed Sobhy Hassan Ghonim Mahfouz, Alaa Abdullah Ali Rahhal, Muhammad Abdulhakim Ali, Ammar Fares Alhaj Issa, Abdul Baki Jasem Senjar, Sumaya Mehdar Al-Saadi Al Yafei, Abdul Rahman Mohammad Said Arab, Awad Razaq Al-Qahtani
Format: Article
Language:English
Subjects:
Blood clots
Body mass index
Cardiology
Cardiomyopathy
Cardiovascular disease
Coronary vessels
Diabetes
Hemoglobin
Hypertension
Patients
Values
Vein & artery diseases
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Summary:Objective: The left ventricular thrombus is one of the serious complications of ischemic cardiomyopathy. In this study, we aimed to search for the independent factors to predict the resolution of left ventricular thrombus. Methods: This retrospective study included all patients with coronary artery disease, aged above 18 years old, and with the thrombus at the apical location of the left ventricle. Demographic, clinical, and echocardiographic characteristics of the patients were recorded. Major adverse cardiovascular events developed within the follow-up period were recorded. The time in the therapeutic range of each patient was calculated. The presence of left ventricular thrombus beyond 180 days despite warfarin usage was classified as persistent left ventricular thrombus. Results: The study included 174 subjects (169 males and 5 females). The mean age of the study population was 54.5 ± 11.0 years. The number of patients in whom the left ventricular thrombus resolved with treatment in less than 180 days was 56 (32.2%). Median anticoagulation time in the study population was 252 [150-480] days and the meantime in the therapeutic range of the patients was 54 ± 19%. The time in therapeutic range value of the groups was similar (P=.593). It was found that concomitant clopidogrel use (P=.003) and left ventricular thrombus area (P < .001) were the independent predictors of left ventricular thrombus resolution within less than 180 days in the logistic regression analysis. Conclusion: Concomitant use of clopidogrel was found to be associated with left ventricular thrombus resolution but left ventricular thrombus size was related to left ventricular thrombus persistency. Although standard 3-6 months of anticoagulation is advised for left ventricular thrombus, considering the presence of these predictors in such patients may guide the physicians to individualize the treatment. Cite this article as: Salah Shabib Ahmed H, Ede H, Sobhy Hassan Ghonim Mahfouz A, et al. Surrogates of the left ventricular thrombus resolution: A retrospective data review. Turk Kardiyol Dern Ars 2022;50(3):168-174.
ISSN:1016-5169
1308-4488
DOI:10.5543/tkda.2022.21068