Spectroscopic Study of the Release Kinetics of Water-Insoluble Drug Griseofulvin from Vaterite Containers in Aqueous Medium

The bioavailability improvement of hydrophobic drugs is one of the major problems in pharmaceutical research as required for the enhancement of their therapeutic efficacy. Encapsulation of such drugs into various micro- and nanocarriers enabling the targeted delivery represents an important strategy...

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Bibliographic Details
Published in:Optics and spectroscopy 2021-07, Vol.129 (7), p.813-820
Main Authors: Saveleva, M. S., Lengert, E. V., Abramova, A. M., Shtykov, S. N., Svenskaya, Yu. I.
Format: Article
Language:English
Subjects:
Aqueous solutions
Bioavailability
Dimethylformamide
Drugs
Encapsulation
Fungicides
Hydrophobicity
Kinetics
Lasers
Optical Devices
Optics
Photonics
Physics
Physics and Astronomy
Raman spectroscopy
Spectroscopic analysis
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Summary:The bioavailability improvement of hydrophobic drugs is one of the major problems in pharmaceutical research as required for the enhancement of their therapeutic efficacy. Encapsulation of such drugs into various micro- and nanocarriers enabling the targeted delivery represents an important strategy here. The process of the designed nanoformulation study generally includes characterization of the payload release profile in model water-based media, which provides a challenge to encapsulated hydrophobic drugs due to their poor solubility in water. Thus, modification of the existed release investigation protocols is required for reliable detection of the liberated hydrophobic drug. Here, we report an optimized multimodal spectroscopic and microscopic study of the release behaviour of griseofulvin (Gf), a water-insoluble antifungal drug, from vaterite carriers. The addition of N,N-dimethylformamide (DMF), a polar aprotic solvent, to aqueous suspensions of Gf-loaded vaterite carriers at the investigated time points right before the UV–Vis spectroscopic measurement allowed us to enhance the accuracy of the released Gf determination. Monitoring of the carrier degradation process by a combination of scanning electron microscopy and Raman spectroscopy demonstrated a good correlation between the obtained data and the payload release kinetics.
ISSN:0030-400X
1562-6911
DOI:10.1134/S0030400X21060126